Dr. Rawad Hodeify has been an Assistant Professor of Medical Biotechnology in the Biotechnology Department since August 2017. He is an elected member of the American Society of Physiology and a member of the Scientific Research Honor Society Sigma Xi, and has received several awards, including achievement awards, research symposium awards, and travel awards for international meetings. He has served as a peer reviewer for the American Journal of Nephrology (2012), Cellular Physiology and Biochemistry (2015), and for F1000Research. He has trained and supervised several graduate and medical students and has judged several scientific research competitions for college and high schools students.
Dr. Hodeify earned his PhD in Interdisciplinary Biomedical Sciences (Cewll and Molecular Biology Track) in the internal medicine department at the University of Arkansas for Medical Sciences and Weill Cornell Medicine, Arkansas, USA in 2011. Dr. Rawad Hodeify earned his Master of Science degree in Biology from the American University of Beirut, Lebanon in 2005, and his Bachelor of Science in Biology Beirut from Lebanese University, Lebanon in 2002.
Dr. Hodeify is broadly interested in understanding the molecular mechanisms that control cell fate decisions under pathological conditions, particularly in kidney diseases and cancer. His research is focused on two areas: dissecting the crosstalk between cycle cell proteins and cell death pathways in kidney injury and regulation of calcium signaling pathways during cellular pathology. Dr. Hodeify and his colleagues have been able to show that cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 and that Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin-induced acute kidney injury. In the area of calcium signaling, he dissected the trafficking dynamics of the store-operated calcium channel Orai1 and found that store-operated calcium influx has a biphasic dependence on Orai1:STIM1 ratio. The current emphasis in Dr. Hodeify’s lab is investigating the role of store-operated calcium entry in cellular pathologies during human diseases, particularly in kidney injury and cancer. In his research, Dr. Hodeify used both cell culture and animal models (Rat, mouse, and frog). He utilized multiple experimental approaches including adenoviral-based techniques, analog sensitive protein kinases, fluorescence and confocal microscopy, calcium imaging, and flow cytometry.
- Hodeify R et al. (2017). “Regulation and Role of Store-Operated Ca2+ Entry in Cellular Proliferation” for a book entitled, ‘Calcium Entry Channels in Non-Excitable Cells”. CRC Press (Taylor and Francis) in the Methods in Signal Transduction Series in ISBN 9781498752725
- El-Najjar N, Kullkarni R, Nader N, Hodeify R, Machaca K. (2017). Effects of hyperglycemia on vascular smooth muscle Ca2+ signaling. Biomed Research International, vol.2017, Article ID 3691349
- Courjaret R, Hodeify R, Hubrack S, Ibrahim A, Dib M, Daas S, Machaca K. The Ca2+-activated Cl- channel Ano1 controls microvilli length and membrane surface area in the oocyte. J Cell Sci. 129: 2548-58 (2016).
- Megyesi J, Tarcsafalvi A, Seng N, Hodeify R, Price PM. Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak. Cell Death Discov. 2: 15066 (2016).
- Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, Al-Thani SN, McGraw T, Machaca K. A STIM1-dependent ‘trafficking trap’ mechanism regulates Orai1 plasma membrane residence and Ca²⁺ influx levels. J Cell Sci. 128: 3143-54 (2015)
- Hodeify R, Megyesi J, Tarcsafalvi A, Mustafa H, Hti Lar Seng NS, Price PM. Gender differences control the susceptibility to ER stress-induced acute kidney injury. American Journal of Physiology 304(7):F875-82 (2013).
- Price PM and Hodeify R. A possible mechanism of renal cell death after ischemia/reperfusion. Kidney International 81, 720–721 (2012).
- Hodeify R, Tarcsafalvi A, Megyesi J, Safirstein RL, Price PM. Cdk2 dependent phosphorylation of p21 Regulates the Role of Cdk2 in Cisplatin Cytotoxicity. American Journal of Physiology Renal Physiology 300(5):F1171-9 (2011).
- Hodeify R, Megyesi J, Tarcsafalvi A, Safirstein RL, Price PM. Protection of Cisplatin Cytotoxicity by an Inactive Cyclin-Dependent Kinase. American Journal of Physiology Renal Physiology 299: F112–F120 (2010).
- Sun L, Hodeify R, Haun S, Charlesworth A, MacNicol A, Ponappan S, Ponappan U, Prigent C, Machaca K. Role of Ca2+ Effectors During Xenopus Oocyte Maturation. Biology of Reproduction 78(4):726-35 (2008).
- Hodeify R, Kreydiyyeh SI. PGE2 Reduces Net Water and Chloride Absorption from the Rat Colon by Targeting the Na+/H+ Exchanger and the Na+K+2Cl- Cotransporter. Prostaglandins, Leukotrienes & Essential Fatty Acids 76(5):285-92 (2007).