Dr. Shoib Siddiqui has been an Assistant Professor in the Biotechnology Department since August 2018 and is teaching General Microbiology, Food Biotechnology, Cell Culture Technology and Research Methodology in the Biological Sciences. Before starting his position at AURAK, he worked as a postdoctoral researcher in the lab of Prof. Ajit Varki at University of California, San Diego (UCSD), California, USA from 2014 through 2018. His research work focused on the role of sialic acids and Siglecs (Sialic acid binding proteins) in cancer, Alzheimer’s, and sepsis. He would like to further focus his research on finding the biomarker and studying the novel pathways associated with cancer progression.
Dr. Shoib has extensively studied cancer in his Ph.D. and postdoctoral research. He did his Ph.D. dissertation at ETH Zurich, Switzerland in the lab of Prof. Michael Detmar. For his Ph.D dissertation, he investigated the role of neuropilin-2 (Nrp2), a cell surface receptor, in skin inflammation and cancer progression. This doctoral research has shed light on the importance of the interaction of vascular endothelial growth factor-C (VEGF-C) with Nrp2 in inflammation. It was found that blocking the VEGF-C/neuropilin-2 interaction led to impaired lymphatic function and increased inflammation in mice. He earned his PhD. from ETH Zurich in 2013. Dr. Shoib obtained his Master of Sciences (M.Sc.) in Biotechnology from the Indian Institute of Technology-Bombay of Powai, Mumbai, India in 2008, which is one of the leading institutes of India.
In his research career, Dr. Shoib has published ground-breaking work in the most reputable journals such as Journal of Clinical Investigation (JCI), PNAS, Blood, Circulation, EMBO and, JBC. One of his unpublished projects led to the submission of a provisional patent in USA. His paper published in Blood has received 162 citations up until now; in total there have been 335 citations of his articles.
- Stanczak*, M.A., Siddiqui*, S.S., Trefny, M.P., Thommen, D.S., Boligan, K.F., von Gunten, S., Tzankov, A., Tietze, L., Lardinois, D., Heinzelmann-Schwarz, V., von Bergwelt-Baildon, M.S., Zhang, W., Lenz, H.J., Han, Y., Amos, C.I., Syedbasha, M., Egli, A., Stenner, F., Speiser, D.E., Varki, A., Zippelius, A., and Läubli, H(2018). Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.(*equal contribution).J Clin Invest. (In Press).
- Siddiqui SS, Springer SA,Verhagen A, Sundaramurthy V, Alisson-Silva F, Jiang W, Ghosh Pand VarkiA (2017).The Alzheimer’s Disease–protective CD33 Splice Variant Mediates Adaptive Loss of Function via Diversion to an Intracellular Pool. J Biol Chem, 292:15312-15320.
- Schwarz F., LandigCS, SiddiquiSS, Secundino I, Olson J, VarkiN, NizetV and VarkiA (2017). Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J, 36, 751-760.
- Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Jiang W, Kim D, Zhou J, Naito-Matsui Y, Chen X, Varki N and Varki A (2017). New findings on the detection, expression, dimerization and ligand binding properties of mouse Siglec-E. J Biol Chem, 292, 1029-1037.
- Läubli, H., da Silva, F.A., Stanczak, M.A., Siddiqui, SS, Deng, L., Verhagen, A., Varki, N., Varki, A. (2014): Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem, 289:33481-33491.
- Läubli, H., Pearce, O.M.T., Schwarz, F., Siddiqui, SS, Deng, L., Stanczak, M., Deng, L., Verhagen, A., Secrest, P., Lusk, C., Schwartz, A.G., Varki, N., Bui, J.D., Varki, A. (2014): Engagement of Myelomonocytic Siglecs by Tumor-associated Ligands Modulates the Innate Immune Response to Cancer. Proc Natl Acad Sci U.S.A., 111:14211-14216.
- Jurisic G*, Maby-El Hajjami H*, Karaman S, Ochsenbein AM, Alitalo A, Siddiqui SS, Ochoa Pereira C, Petrova TV, Detmar M. (2012): An unexpected role of semaphorin 3A/neuropilin-1 signaling in lymphatic vessel maturation and valve formation. Circulation Research, 111: 426-36.
- Huggenberger R, Siddiqui SS, Brander D, Ullmann S, Zimmermann K, Antsiferova M, Werner S, Alitalo K, Detmar M. (2011): An important role of lymphatic vessel activation in limiting acute inflammation. Blood, 117: 4667-78.
Provisional Patent Submitted
- Siddiqui SS, Verhagen A, Varki N, Varki A. Detection of genetic variation in cancer risk (2018).