Dr. Rawad Hodeify

Dr. Rawad Hodeify is an Associate Professor of Medical Biotechnology at the American University of Ras Al Khaimah and the Chair of the Biotechnology Department. He earned his Ph.D. in Interdisciplinary Biomedical Sciences (Cell and Molecular Biology Track) from the University of Arkansas for Medical Sciences (UAMS), USA in 2011. He worked as a Post-Doctoral Fellow in the Department of Internal Medicine, UAMS, USA between 2011-2013. In 2013, Dr Hodeify joined Weill Cornell Medicine – Qatar as Post-Doctoral Research Associate till 2017. Dr. Hodeify has also completed a postgraduate degree in Artificial Intelligence and Machine Learning (PGP-AIML) from University of Texas at Austin in 2022. With a broad background in interdisciplinary biomedical sciences, specifically molecular and cellular biology, Dr. Hodeify research portfolio focuses on three themes: (1) the crosstalk between cell cycle, cell death, and calcium signaling during cellular pathology particularly in kidney injury and cancer, (2) regulation of trafficking of membrane proteins, precisely, store-operated calcium channel (Orai1) and sodium potassium pump, (3) applying AI and machine learning models for predicting cellular fate, disease progression, and early diagnosis.

• Leadership Principles
  Harvard Business School Online – August 2023

• Artificial Intelligence in Healthcare
  MIT SLOAN School of Management
  2022
  
• Graduate Program in Artificial Intelligence and Machine Learning
  The McCombs School of Business, The University of Texas at Austin, USA
  2021 - 2022
  
• Doctor of Philosophy in Interdisciplinary Biomedical Sciences
  University of Arkansas for Medical Sciences, Arkansas, USA
  2005 - 2011
  
• Master of Science in Biology
  American University of Beirut, Lebanon
  2002 - 2005
  
• Bachelor of Science in Biology
  Lebanese University, Lebanon
  1998 - 2002

Research Publications

• Hodeify R, Kreydiyyeh S, Zaid LMJ. Identified and potential internalization signals involved in trafficking and regulation of Na+/K+ ATPase activity. Mol Cell Biochem. 2023 Aug 27. doi: 10.1007/s11010-023-04831-y. Epub ahead of print. PMID: 37634170.
• Aboud O, Liu Y, Dahabiyeh L, Abuaisheh A, Li F, Aboubechara JP, Riess J, Bloch O, Hodeify R, Tagkopoulos I, Fiehn O. Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment. Biomedicines. 2023 Aug 13;11(8):2261. doi: 10.3390/biomedicines11082261. PMID: 37626757; PMCID: PMC10452138.
• Siddiqui SS, Hodeify R, Mathew S, Alsawaf S, Alghfeli A, Matar R, Merheb M, Marton J, Al Zouabi HA, Sethuvel DPM, Ragupathi NKD, Vazhappilly CG. Differential dose-response effect of cyclosporine A in regulating apoptosis and autophagy markers in MCF-7 cells. Inflammopharmacology. 2023 Aug;31(4):2049-2060. doi: 10.1007/s10787-023-01247-4. Epub 2023 May 19. PMID: 37204695.
  
• Aboud O, Liu YA, Fiehn O, Brydges C, Fragoso R, Lee HS, Riess J, Hodeify R, Bloch O. Application of Machine Learning to Metabolomic Profile Characterization in Glioblastoma Patients Undergoing Concurrent Chemoradiation. Metabolites. 2023 Feb 17;13(2):299. doi: 10.3390/metabo13020299. PMID: 36837918; PMCID: PMC9961856.
  
• Ghani, A.; Hodeify, R.; See, C.H.; Keates, S.; Lee, D.-J.; Bouridane, A. Computer Vision-Based Kidney’s (HK-2) Damaged Cells Classification with Reconfigurable Hardware Accelerator (FPGA). Electronics 2022, 11, 4234.
  https://doi.org/10.3390/electronics11244234
• Alhajeri MM, Alkhanjari RR, Hodeify R, Khraibi A, Hamdan H. Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development. Front Cell Dev Biol. 2022 Sep 23;10:980219. doi: 10.3389/fcell.2022.980219. PMID: 36211465; PMCID: PMC9537470.
• Hodeify R, Ghani A, Matar R, Vazhappilly CG, Merheb M, Zouabi HA, Marton J. Adenosine Triphosphate Protects from Elevated Extracellular Calcium-Induced Damage in Human Proximal Kidney Cells: Using Deep Learning to Predict Cytotoxicity. Cell Physiol Biochem. 2022 Sep 21;56:484-499. doi: 10.33594/000000571. PMID: 36126285.
• Khalil C, Hodeify R, Kreydiyyeh S. Signaling Cascade Mediating the Effect of FTY720P on the Na+/K+ ATPase in LLC-PK1. Cell Physiol Biochem. 2022 Aug 29;56(4):418-435. doi: 10.33594/000000561. PMID: 36041048.
• Rida R, Hodeify R, Kreydiyyeh S. Adverse effect of FTY720P on colonic Na+ /K+ ATPase is mediated via ERK, p38MAPK, PKC, and PI3K. J Appl Toxicol. 2022 Aug 9. doi: 10.1002/jat.4375. Epub ahead of print. PMID: 35946054.
• Nader N, Dib M, Hodeify R, Courjaret R, Elmi A, Hammad AS, Dey R, Huang XY, Machaca K. Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2. PLoS Biol. 2021 Feb 10;19(2):e3001117. doi: 10.1371/journal.pbio.3001117. Erratum for: PLoS Biol. 2020 Nov 2;18(11):e3000901. PMID: 33566812; PMCID: PMC7875357.
• Hodeify R, Siddiqui SS, Matar R, Vazhappilly CG, Merheb M, Al Zouabi H, Marton J. Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells. Heliyon. 2021 Jan 22;7(1):e06041. doi: 10.1016/j.heliyon.2021.e06041. PMID: 33532651; PMCID: PMC7829211.
• Hodeify R, Dib M, Alcantara-Adap E, Courjaret R, Nader N, Reyes CZ, Hammad AS, Hubrack S, Yu F, Machaca K. The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis. Sci Rep. 2021 Jan 27;11(1):2290. doi: 10.1038/s41598-021-82048-z. PMID: 33504898; PMCID: PMC7840751.
• Hodeify R, Chakkour M, Rida R, Kreydiyyeh S. PGE2 upregulates the Na+/K+ ATPase in HepG2 cells via EP4 receptors and intracellular calcium. PLoS One. 2021 Jan 14;16(1):e0245400. doi: 10.1371/journal.pone.0245400. PMID: 33444342; PMCID: PMC7808645.
• Vazhappilly CG, Hodeify R, Siddiqui SS, Laham AJ, Menon V, El-Awady R, Matar R, Merheb M, Marton J, Al Zouabi HAK, Radhakrishnan R. Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells. Phytother Res. 2021 Apr;35(4):2185-2199. doi: 10.1002/ptr.6970. Epub 2020 Dec 7. PMID: 33289235.
• Hodeify R, Dib M, Alcantara-Adap E, Courjaret R, Nader N, Reyes CZ, Hammad AS, Hubrack S, Yu F, Machaca K. The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis. Sci Rep. (2021).
• Hodeify R, Siddiqui SS, Matar R, Vazhappilly CG, Merheb M, Al Zouabi H, Marton J. Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells. Heliyon. (2021)
• Hodeify R, Nandakumar, M., Own, M., Courjaret, R. J., Graumann, J., Hubrack, S. Z., & Machaca, K. The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking. Science advances, 4(9), eaau1935. doi:10.1126/sciadv.aau1935, (2018).

• BIOL 112 University Biology
• BIOL 114 University Biology II
• BIOL 330 Applied and Industrial Microbiology
• BIOL 356 Virology
• BIOL 322 Microbial Genetics
• BIOL 434 Cell Communication and Signal Transduction
• BIOL 450 Bioethics
• BIOL 440 Medical Microbiology
• BIOL 442 Molecular Diagnostics
• BIOL 443 Molecular Diagnostics Lab
• BIOL 491 Senior Seminar
• BIOL 494 Senior Project in Cell and Molecular Biotechnology